Egyptian scene depicting the preparation of Lily perfume. The word perfume used today derives from the Latin "per fumum", meaning through smoke. Perfumery, or the art of making perfumes, began in ancient Mesopotamia and Egypt but was developed and further refined by the Romans and Persians. Although perfume and perfumery also existed in East Asia, much of its fragrances are incense based.

The world's first recorded chemist is considered to be a person named Tapputi, a perfume maker who was mentioned in a cuneiform tablet from the second millennium BC in Mesopotamia.

Recently, archaeologists have uncovered what is believed to be the world's oldest perfumes in Pyrgos, Cyprus. The perfumes date back more than 4,000 years. The perfumes were discovered in an ancient perfumery factory. At least 60 distilling stills, mixing bowls, funnels and perfume bottles were found in the 43,000-square-foot (4,000 m²) factory. In ancient times people used herbs and spices, like almond, coriander, myrtle, conifer resin, bergamot, but not flowers.

The Persian doctor and chemist Avicenna introduced the process of extracting oils from flowers by means of distillation, (the procedure most commonly used today). He first experimented with the rose. Until his discovery, liquid perfumes were mixtures of oil and crushed herbs, or petals which made a strong blend. Rose water was more delicate, and immediately became popular. Both of the raw ingredients and distillation technology significantly influenced western perfumery and scientific developments, particularly chemistry.

Knowledge of perfumery came to Europe as early as the 14th century due partially to the spread of Islam. But it was the Hungarians who ultimately introduced the first modern perfume. The first modern perfume, made of scented oils blended in an alcohol solution, was made in 1370 at the command of Queen Elizabeth of Hungary and was known throughout Europe as Hungary Water. The art of perfumery prospered in Renaissance Italy, and in the 16th century, Italian refinements were taken to France by Catherine de' Medici's personal perfumer, Rene le Florentin. His laboratory was connected with her apartments by a secret passageway, so that no formulas could be stolen en route. France quickly became the European center of perfume and cosmetic manufacture. Cultivation of flowers for their perfume essence, which had begun in the 14th century, grew into a major industry in the south of France. During the Renaissance period, perfumes were used primarily by royalty and the wealthy to mask body odors resulting from the sanitary practices of the day. Partly due to this patronage, the western perfumery industry was created. By the 18th century, aromatic plants were being grown in the Grasse region of France to provide the growing perfume industry with raw materials. Even today, France remains the centre of the European perfume design and trade.

Top notes: The scents that are perceived immediately on application of a perfume. Top notes consist of small, light molecules that evaporate quickly. They form a person's initial impression of a perfume and thus are very important in the selling of a perfume. The scents of this note class are usually described as "fresh," "assertive" or "sharp." The compounds that contribute to top notes are strong in scent, very volatile, and evaporate quickly. Citrus and ginger scents are common top notes. Also called the head notes.
Middle notes: The scent of a perfume that emerges just prior to when the top notes dissipate. The middle note compounds form the "heart" or main body of a perfume and act to mask the often unpleasant initial impression of base notes, which become more pleasant with time. Not surprisingly, the scent of middle note compounds is usually more mellow and "rounded." Scents from this note class appear anywhere from two minutes to one hour after the application of a perfume. Lavender and rose scents are typical middle notes. They are also called the "heart notes".
Base notes: The scent of a perfume that appears close to the departure of the middle notes. The base and middle notes together are the main theme of a perfume. Base notes bring depth and solidity to a perfume. Compounds of this class are often the fixatives used to hold and boost the strength of the lighter top and middle notes. Consisting of large, heavy molecules that evaporate slowly, compounds of this class of scents are typically rich and "deep" and are usually not perceived until 30 minutes after the application of the perfume or during the period of perfume dry-down. Some base notes can still be detectable in excess of twenty-four hours after application, particularly the animalic notes.